Document Detail


Fluorous supported modular synthesis of heparan sulfate oligosaccharides.
MedLine Citation:
PMID:  23293947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The modular synthesis of heparan sulfate fragments is greatly facilitated by employing an anomeric aminopentyl linker protected by a benzyloxycarbonyl group modified by a perfluorodecyl tag, which made it possible to purify highly polar intermediates by fluorous solid phase extraction. This tagging methodology made it also possible to perform repeated glycosylations to drive reactions to completion.
Authors:
Chengli Zong; Andre Venot; Omkar Dhamale; Geert-Jan Boons
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-08
Journal Detail:
Title:  Organic letters     Volume:  15     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-18     Completed Date:  2013-05-14     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  342-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Glycosylation
Heparitin Sulfate / chemical synthesis*,  chemistry
Indicators and Reagents
Molecular Structure
Oligosaccharides / chemical synthesis*,  chemistry
Solid Phase Extraction
Grant Support
ID/Acronym/Agency:
2R01GM065248/GM/NIGMS NIH HHS; R01 GM065248/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Indicators and Reagents; 0/Oligosaccharides; 9050-30-0/Heparitin Sulfate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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