Document Detail

Fluoroquinolones and tendon disorders.
MedLine Citation:
PMID:  15794721     Owner:  NLM     Status:  MEDLINE    
Fluoroquinolones are the most potent oral antibiotics in clinical use today. Increasingly, these drugs are being prescribed for relatively benign infections and for new categories of patients, including paediatric patients. As their use becomes more frequent, so will the adverse events. This review focuses on a rare but debilitating adverse reaction, the fluoroquinolone-associated tendinopathy. Despite many published case reports and approximately 3500 cases reported to the World Health Organization Collaborating Centre for Drug Monitoring, little is known about the mechanisms behind this fluoroquinolone-specific toxicity. Data on chemical properties, mode of action, pharmacokinetic features, clinical presentation and risk factors in relation to tendon toxicity are discussed and the literature reviewed. As long as the musculoskeletal toxicity cannot be predicted by in vitro or in vivo models and this class of antibiotics is one of the most commonly linked to selection of resistant bacteria, a more prudent use of fluoroquinolones is warranted.
Asa Melhus
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on drug safety     Volume:  4     ISSN:  1744-764X     ISO Abbreviation:  Expert Opin Drug Saf     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-29     Completed Date:  2005-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101163027     Medline TA:  Expert Opin Drug Saf     Country:  England    
Other Details:
Languages:  eng     Pagination:  299-309     Citation Subset:  IM    
Lund University, Department of Medical Microbiology, Malmö University Hospital, S-205 02 Malmö, Sweden.
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MeSH Terms
Achilles Tendon / drug effects
Disease Models, Animal
Drug Resistance, Bacterial
Fluoroquinolones / adverse effects*,  pharmacokinetics
Middle Aged
Musculoskeletal Diseases / chemically induced*,  epidemiology
Risk Factors
Rupture, Spontaneous
Sweden / epidemiology
Tendinopathy / chemically induced,  epidemiology
Tendons / drug effects*
Reg. No./Substance:

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