| Fluoroquinolones and tendon disorders. | |
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MedLine Citation:
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PMID: 15794721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fluoroquinolones are the most potent oral antibiotics in clinical use today. Increasingly, these drugs are being prescribed for relatively benign infections and for new categories of patients, including paediatric patients. As their use becomes more frequent, so will the adverse events. This review focuses on a rare but debilitating adverse reaction, the fluoroquinolone-associated tendinopathy. Despite many published case reports and approximately 3500 cases reported to the World Health Organization Collaborating Centre for Drug Monitoring, little is known about the mechanisms behind this fluoroquinolone-specific toxicity. Data on chemical properties, mode of action, pharmacokinetic features, clinical presentation and risk factors in relation to tendon toxicity are discussed and the literature reviewed. As long as the musculoskeletal toxicity cannot be predicted by in vitro or in vivo models and this class of antibiotics is one of the most commonly linked to selection of resistant bacteria, a more prudent use of fluoroquinolones is warranted. |
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Authors:
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Asa Melhus |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on drug safety Volume: 4 ISSN: 1744-764X ISO Abbreviation: Expert Opin Drug Saf Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-29 Completed Date: 2005-12-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101163027 Medline TA: Expert Opin Drug Saf Country: England |
Other Details:
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Languages: eng Pagination: 299-309 Citation Subset: IM |
Affiliation:
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Lund University, Department of Medical Microbiology, Malmö University Hospital, S-205 02 Malmö, Sweden. asa.melhus@mikrobiol.mas.lu.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Achilles Tendon
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drug effects Adult Aged Animals Child Disease Models, Animal Drug Resistance, Bacterial Female Fluoroquinolones / adverse effects*, pharmacokinetics Humans Incidence Male Middle Aged Musculoskeletal Diseases / chemically induced*, epidemiology Risk Factors Rupture, Spontaneous Sweden / epidemiology Tendinopathy / chemically induced, epidemiology Tendons / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Fluoroquinolones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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