| Fluoroquinolone concentrations in plasma, urine, and bile after oral administration in rats with renal failure: useful technique for long-term bile collection. | |
| | |
MedLine Citation:
|
PMID: 11958277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Using a previously reported technique for bile collection, we studied the pharmacokinetics of levofloxacin (LVFX) and grepafloxacin (GPFX) in normal rats and in animals with renal failure. Continuous bile drainage was performed using normal and renal-failure Wistar rats. Oral GPFX or LVFX (40 mg/Kg) was administered. The drug concentrations in plasma, urine, and bile were determined by high-performance liquid chromatography. The area under the blood concentration-time curve (AUC) in each renal-failure rat was calculated. There were no significant differences in GPFX concentrations in the serum, urine, and bile between the renal-failure and normal rats, but the LVFX level in the urine of the renal-failure group was statistically significantly lower than in the normal group. The AUC of GPFX had an opposite correlation with the degree of renal failure, but that of LVFX was correlated. |
| | |
Authors:
|
K Mizuta; S Hishikawa; M Hirota; G Miyamoto; A Fujimura; Y Hakamata; E Kobayashi |
Related Documents
:
|
2809397 - High-protein feeding stimulates renal thromboxane production in rats with streptozocin-... 1996717 - Role of renal nerves in sodium retention of cirrhosis and congestive heart failure. 8853427 - Site-specific regulation of organic osmolytes along the rat nephron. 20728477 - Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes. 15215567 - Preliminary phenotypic characterization of the warsaw high preferring (whp) and warsaw ... 7969777 - Immunocytochemical mapping of a novel dopamine-releasing protein in the rat brain. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of medicine Volume: 32 ISSN: 0025-7850 ISO Abbreviation: J Med Publication Date: 2001 |
Date Detail:
|
Created Date: 2002-04-17 Completed Date: 2002-04-30 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7505566 Medline TA: J Med Country: United States |
Other Details:
|
Languages: eng Pagination: 311-20 Citation Subset: IM |
Affiliation:
|
Department of Clinical Pharmacology, Center for Molecular Medicine, Jichi Medical School, Tochigi, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Animals Anti-Infective Agents / analysis, blood*, urine* Bile / chemistry* Blood Urea Nitrogen Fluoroquinolones* Kidney Failure / metabolism* Male Ofloxacin / analysis, blood*, urine* Osmolar Concentration Piperazines / analysis, blood*, urine* Rats Rats, Wistar Reference Values Specimen Handling / methods |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Infective Agents; 0/Fluoroquinolones; 0/Piperazines; 119914-60-2/grepafloxacin; 82419-36-1/Ofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A case of papillary muscle rupture caused by acute myocardial infarction.
Next Document: Cardiac pacing as emergency care for serious bradyarrhythmia with circulatory shock.