Document Detail

Fluoroenzymometric method to measure cardiac troponin I in sera of patients with myocardial infarction.
MedLine Citation:
PMID:  8787705     Owner:  NLM     Status:  MEDLINE    
The aim of our study was to evaluate the clinical relevance of serum troponin I (TnI) as a marker of ischemic myocardial injury by using an automated fluoroenzymometric assay. The reference range for serum TnI was established by measuring serum TnI concentrations in blood from 75 healthy donors. The concentration was then compared with serum creatine kinase (CK) activity, CK-MB mass, and myoglobin concentrations in 20 patients with myocardial infarction diagnosed according to the WHO criteria, 20 patients with chest pain of nonischemic origin, 9 patients with unstable angina, 11 with stable angina, 11 patients with chronic muscular diseases, 6 patients with muscular trauma without chest contusion, and 13 patients with chronic renal disease. We found that: (a) 99% of the blood donors had TnI concentrations <0.26 microgram/L (detection limit of the assay in our study); (b) TnI values in acute myocardial infarction (AMI) patients 4 h after onset of chest pain showed a sensitivity of 0.769 and a specificity of 1.0 at a decisional concentration for AMI of 1 microgram/L, even in the presence of severe skeletal muscle injuries or renal diseases; (c) the increase in TnI concentrations after infarction (interquartile range 3.25-6 h) and the peak occurred later (interquartile range 11.5-24 h) than the rise found in myoglobin and CK-MB, but the increase persisted much longer (>96 h); (d) receiver-operating characteristic curve analysis showed the high diagnostic accuracy of TnI in diagnosing AMI even in patients in whom traditional biochemical markers are adversely influenced by underlying clinical situations.
M Zaninotto; S Altinier; M Lachin; P Carraro; M Plebani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  42     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-10-22     Completed Date:  1996-10-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1460-6     Citation Subset:  IM    
Laboratorio Centrale, Azienda Ospedaliera di Padova, Italy.
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MeSH Terms
Aged, 80 and over
Creatine Kinase / blood
Middle Aged
Myocardial Infarction / blood,  diagnosis*
Myoglobin / analysis
Time Factors
Troponin / blood*
Troponin I
Reg. No./Substance:
0/Isoenzymes; 0/Myoglobin; 0/Troponin; 0/Troponin I; EC Kinase

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