| Fluorodeoxyglucose positron emission tomography (FDG-PET) for monitoring lymphadenopathy in the autoimmune lymphoproliferative syndrome (ALPS). | |
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MedLine Citation:
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PMID: 16432855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autoimmune lymphoproliferative syndrome (ALPS) is associated with mutations that impair the activity of lymphocyte apoptosis proteins, leading to chronic lymphadenopathy, hepatosplenomegaly, autoimmunity, and an increased risk of lymphoma. We investigated the utility of fluorodeoxyglucose positron emission tomography (FDG-PET) in discriminating benign from malignant lymphadenopathy in ALPS. We report that FDG avidity of benign lymph nodes in ALPS can be high and, hence, by itself does not imply presence of lymphoma; but FDG-PET can help guide the decision for selecting which of many enlarged nodes in ALPS patients to biopsy when lymphoma is suspected. |
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Authors:
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V Koneti Rao; Jorge A Carrasquillo; Janet K Dale; Stephen L Bacharach; Millie Whatley; Faith Dugan; Jean Tretler; Thomas Fleisher; Jennifer M Puck; Wyndham Wilson; Elaine S Jaffe; Nilo Avila; Clara C Chen; Stephen E Straus |
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Publication Detail:
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Type: Case Reports; Clinical Trial; Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: American journal of hematology Volume: 81 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-30 Completed Date: 2006-04-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 81-5 Citation Subset: IM |
Copyright Information:
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2006 Wiley-Liss, Inc. |
Affiliation:
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Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1888, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmune Diseases
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diagnosis,
pathology Biopsy Diagnosis, Differential Female Fluorodeoxyglucose F18 / diagnostic use* Humans Lymph Nodes / pathology Lymphatic Diseases / diagnosis*, pathology Lymphoma / diagnosis* Lymphoproliferative Disorders / diagnosis*, immunology, pathology Male Mutation Positron-Emission Tomography / methods*, standards Prospective Studies |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
Erratum In:
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Am J Hematol. 2006 May;81(5):389 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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