| Fluorodeoxyglucose Positron Emission Tomography in Primary Thyroid Lymphoma with Coexisting Lymphocytic Thyroiditis. | |
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MedLine Citation:
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PMID: 21875367 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Primary thyroid lymphoma is an uncommon neoplasm frequently associated with lymphocytic thyroiditis (LT). Once the pathologic diagnosis of primary thyroid lymphoma is established, imaging plays an important role in tumor staging and evaluating treatment response. The present case discusses the role of fluorodeoxyglucose positron emission tomography ((18)F-FDG PET)/computed tomography (CT) in this clinical setting along with the potential diagnostic challenges. Patient Findings: A 44-year-old man with a history of LT and hypothyroidism presented with an enlarging goiter. Initial imaging evaluation showed markedly enlarged gland with bilateral cervical and mediastinal adenopathy. Histopathologic evaluation confirmed the diagnosis of primary thyroid lymphoma on a background of LT. An (18)F-FDG PET/CT revealed increased uptake in the gland and lymph nodes. Follow-up (18)F-FDG PET/CT after chemotherapy showed interval decrease in FDG uptake in the thyroid gland associated with interval decrease in the size and metabolic activity of the cervical and superior mediastinal lymph nodes. Conclusions: The frequent association of LT with primary thyroid lymphoma and the overlap of their clinical and pathologic findings pose a significant diagnostic challenge. While other imaging techniques are helpful in evaluating anatomic local and regional extent of primary thyroid lymphoma, (18)F-FDG PET/CT can be of an added value in evaluating its metabolic activity and detecting regional and distant disease as well as in assessing response to treatment. |
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Authors:
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Mohammad Arabi; Ryan Dvorak; Lauren B Smith; Lisa Kujawski; Milton D Gross |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-29 |
Journal Detail:
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Title: Thyroid : official journal of the American Thyroid Association Volume: - ISSN: 1557-9077 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9104317 Medline TA: Thyroid Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Division of Nuclear Medicine, Department of Radiology, University of Michigan Health Systems , Ann Arbor, Michigan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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