Document Detail


Fluorocitrate inhibition of aconitase: relative configuration of inhibitory isomer by x-ray crystallography.
MedLine Citation:
PMID:  5481856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fluorocitrate isomer that is a strong inhibitor and inactivator of aconitase has been shown by x-ray crystallographic studies on the rubidium ammonium salt to have the configurations (1R : 2R) or (1S : 2S) 1-fluoro-2-hydroxy-1,2,3-propanetricarboxylic acid. A possible mechanism for the action of fluorocitrate is proposed which involves the 1R : 2R isomer suggested from biochemical data.
Authors:
H L Carrell; J P Glusker; J J Villafranca; A S Mildvan; R J Dummel; E Kun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  170     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1970 Dec 
Date Detail:
Created Date:  1971-01-13     Completed Date:  1971-01-13     Revised Date:  2011-12-08    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1412-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Citrates / pharmacology*
Fluorine / pharmacology*
Fluoroacetates / pharmacology
Hydro-Lyases / antagonists & inhibitors*
Stereoisomerism
X-Ray Diffraction*
Chemical
Reg. No./Substance:
0/Citrates; 0/Fluoroacetates; 7782-41-4/Fluorine; EC 4.2.1.-/Hydro-Lyases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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