| Fluorocarbon perfusion medium applied to the isolated rat brain. | |
| | |
MedLine Citation:
|
PMID: 7453195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In order to overcome the disadvantages of erythrocytes and albumin, a totally synthetic medium for the perfusion of the isolated rat brain was developed. the perfusion medium was based upon Krebs-Henseleit solution and contained in addition a fluorocarbon (FC 43) for oxygen transport and a polyol (Pluronic F 68) to furnish emulsifying and oncotic properties. The physico-chemical properties of this fluorocarbon perfusion medium allowed perfusion of an isolated rat brain to continue for more than 7 hr, while the medium could be stored as a stock emulsion for several months. The appropriate function of the isolated perfused rat brain is demonstrated by the EEG and by various substrates of the energy metabolism. The suitability of the fluorocarbon medium for perfusion of an isolated rat brain preparation is discussed. |
| | |
Authors:
|
B Dirks; J Krieglstein; H H Lind; H Rieger; H Schütz |
Related Documents
:
|
2268905 - Salivary excretion of 5-fluorouracil (5-fu). v. effect of 5-fu concentration in perfusa... 21423385 - Cyclooxygenase-2 inhibition restored endothelium-mediated relaxation in old obese zucke... 11397395 - First-pass metabolism of 1,3-butadiene in once-through perfused livers of rats and mice. 1208645 - Pharmacological effects of urotensins. iii. fate or urotensin i in different vascular b... 101435 - Prenatal development of acid beta-glycosidases in the rat liver, effect of triiodothyro... 1977235 - Sex-related incidence of tubular metaplasia in bowman's capsule of aging rats. |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of pharmacological methods Volume: 4 ISSN: 0160-5402 ISO Abbreviation: J Pharmacol Methods Publication Date: 1980 Sep |
Date Detail:
|
Created Date: 1981-03-17 Completed Date: 1981-03-17 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7806596 Medline TA: J Pharmacol Methods Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 95-108 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Substitutes / pharmacology* Brain / metabolism, physiology* Chemical Phenomena Chemistry Electroencephalography Energy Metabolism Fluorocarbons / pharmacology* Glucose / metabolism Male Perfusion* Rats |
| Chemical | |
Reg. No./Substance:
|
0/Blood Substitutes; 0/Fluorocarbons; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quantitative estimation of overadditive and underadditive drug effects by means of theoretical, addi...
Next Document: Medicinal and toxic plants from Equatorial Africa: a pharmacologic approach.