| Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging in patients with carcinoma of the nasopharynx: diagnostic accuracy and impact on clinical management. | |
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MedLine Citation:
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PMID: 17324532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess the value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma as compared with PET and conventional imaging (CI) alone, and to assess the impact of PET/CT on further clinical management. METHODS AND MATERIALS: Thirty-three patients with nasopharyngeal carcinoma had 45 PET/CT examinations. The study was a retrospective analysis. Changes in patient care resulting from the PET/CT studies were recorded. RESULTS: Positron emission tomography/computed tomography had sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 92%, 90%, 90%, 90%, and 91%, respectively, as compared with 92%, 65%, 76%, 86%, and 80% for PET and 92%, 15%, 60%, 60%, and 60% for CI. Imaging with PET/CT altered further management of 19 patients (57%). Imaging with PET/CT eliminated the need for previously planned diagnostic procedures in 11 patients, induced a change in the planned therapeutic approach in 5 patients, and guided biopsy to a specific metabolically active area inside an edematous region in 3 patients, thus decreasing the chances for tissue sampling errors and avoiding damage to nonmalignant tissue. CONCLUSIONS: In cancer of the nasopharynx, the diagnostic performance of PET/CT is better than that of stand-alone PET or CI. Positron emission tomography/computed tomography had a major impact on further clinical management in 57% of patients. |
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Authors:
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Arie Gordin; Avishay Golz; Marcello Daitzchman; Zohar Keidar; Rachel Bar-Shalom; Abraham Kuten; Ora Israel |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2007-02-26 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 68 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-14 Completed Date: 2007-06-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 370-6 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Rambam Health Care Campus, Haifa, Israel. ariegor@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Carcinoma, Squamous Cell / radiography, radionuclide imaging*, secondary Child False Negative Reactions False Positive Reactions Female Fluorodeoxyglucose F18 / diagnostic use* Humans Male Middle Aged Nasopharyngeal Neoplasms / radiography, radionuclide imaging* Neoplasm Recurrence, Local / radiography, radionuclide imaging Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use* Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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