| Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patients. | |
| | |
MedLine Citation:
|
PMID: 8781149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fluorine-18 deoxyglucose (FDG) is not a very tumour-specific substance, and its accumulation in benign lesions with increased glucose metabolism may give rise to false-positive results and hence cause FDG positron emission tomography (PET) to display relatively low specificity (frequently below 85%). Correct interpretation of FDG PET studies is predicated upon detailed knowledge of morphological abnormalities, and the importance of the correlation of functional and morphological information, as derived from computed tomography or magnetic resonance imaging, is discussed. It is emphasized that image fusion programs cannot substitute for understanding of functional and morphological methods. The reconstruction of PET cross-sections is considered, and it is concluded that an iterative image reconstruction method is to be favoured, given its advantages in reducing image artefacts and improving quantification of radioactivity concentrations. The differentiation of malignant and benign lesions when using FDG PET is then reviewed; false-positive findings may be obtained, for example, in patients with acute inflammatory lesions, chronic pancreatitis, retroperitoneal fibrosis or salivary gland tumours. It is suggested that these problems may be alleviated by means of multitracer studies, e.g. using carbon-11 labelled aminoisobutyric acid for quantification of A-type amino acid transport. Finally, the effects of radiotherapy and chemotherapy on FDG uptake and the problems that accrue from these effects are reviewed. Both radiotherapy and chemotherapy can cause increased FDG uptake, complicating diagnosis and evaluation. Knowledge of the effects of different treatment procedures on regional FDG metabolism is therefore necessary for correct interpretation of the PET data. |
| | |
Authors:
|
L G Strauss |
Related Documents
:
|
18795299 - Comparison of mri (including ss se-epi and spio-enhanced mri) and fdg-pet/ct for the de... 16626889 - Fdg-pet/ct in the evaluation of anal carcinoma. 9371879 - The value of quantitative gallium-67 single-photon emission tomography in the clinical ... 18650179 - [18f]fluorodeoxyglucose positron emission tomography scanning for staging, response ass... 15513519 - A case of cervical paraganglioma: usefulness of fdg pet imaging and a possibility of ra... 21061189 - Small lesions detectability with the biograph 16 hi-rez pet/ct scanner and fast imaging... 6330089 - Biosynthesis of the epidermal growth factor receptor in human epidermoid carcinoma-deri... 10036709 - Helical ct angiography of transjugular intrahepatic portosystemic shunts. 11522489 - Determination of the disintegration behavior of magnetically marked tablets. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: European journal of nuclear medicine Volume: 23 ISSN: 0340-6997 ISO Abbreviation: Eur J Nucl Med Publication Date: 1996 Oct |
Date Detail:
|
Created Date: 1996-11-01 Completed Date: 1996-11-01 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 7606882 Medline TA: Eur J Nucl Med Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 1409-15 Citation Subset: IM |
Affiliation:
|
Medical PET Group--Biological Imaging, Department of Oncological Diagnosis and Therapy, German Cancer Research Center, Heidelberg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Artifacts Deoxyglucose / analogs & derivatives*, diagnostic use False Positive Reactions Fluorine Radioisotopes / diagnostic use* Fluorodeoxyglucose F18 Humans Image Processing, Computer-Assisted / methods Neoplasms / radionuclide imaging*, therapy Sensitivity and Specificity Tomography, Emission-Computed* |
| Chemical | |
Reg. No./Substance:
|
0/Fluorine Radioisotopes; 154-17-6/Deoxyglucose; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nuclear medicine training in china.
Next Document: The use of color-coded duplex scanning in the selection of patients with lower extremity arterial di...