Document Detail


Fluorine-18 DOPA PET imaging of paraganglioma syndrome.
MedLine Citation:
PMID:  16374125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 12-year-old boy was admitted after recently having had a resection performed of an extraadrenal retroperitoneal paraganglioma and left adrenalectomy for pheochromocytoma. Despite these procedures, the blood pressure and urinary noradrenalin were elevated. Screening with fluorine-18 DOPA PET demonstrated increased tracer uptake in the right adrenal gland, in a second abdominal lesion, which was prevertebral, and 2 cervical hot spots near the carotid bifurcation, one on each side of the neck. The patient carries a mutation of the gene Succinate dehydrogenasis subunits D (SDHD) and is thus classified with the paraganglioma syndrome type 1.
Authors:
Ingo Brink; Oliver Schaefer; Martin Walz; Hartmut P H Neumann
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  31     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-23     Completed Date:  2006-05-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-41     Citation Subset:  IM    
Affiliation:
Department of Radiology, Albert-Ludwigs-University, Freiburg, Germany. ingo.brink@uniklinik-freiburg.de
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MeSH Terms
Descriptor/Qualifier:
Abdominal Neoplasms / genetics,  radionuclide imaging*
Child
Dihydroxyphenylalanine / analogs & derivatives*,  diagnostic use
Head and Neck Neoplasms / genetics,  radionuclide imaging*
Humans
Male
Paraganglioma / genetics,  radionuclide imaging*
Positron-Emission Tomography / methods*
Radiopharmaceuticals / diagnostic use
Succinate Dehydrogenase / genetics
Syndrome
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 63-84-3/Dihydroxyphenylalanine; 75290-51-6/fluorodopa F 18; EC 1.3.99.1/Succinate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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