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Fluorinated Compounds Against Mycobacterium Tuberculosis.
MedLine Citation:
PMID:  24111908     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Tuberculosis is a severe infectious disease currently being treated with drugs that were developed more than 40 years ago. In recent years, the emergence of resistant Mycobacterium tuberculosis strains, as well as co-infection with the AIDS virus, has caused global concern about the evolution of the disease. Thus, the search for new drugs has become a necessity and a great challenge. Fluorine is a strategic element that is very useful in medicinal chemistry for its great influence on the biological activity of substances. This review highlights the importance of fluorinated molecules that are currently in clinical use or pre-clinical phases of development. Further, some substances in the prototype development stage are cited, which potentially represent future alternatives for the treatment of tuberculosis.
Authors:
Núbia Boechat; Mônica M Bastos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-10
Journal Detail:
Title:  Current topics in medicinal chemistry     Volume:  -     ISSN:  1873-4294     ISO Abbreviation:  Curr Top Med Chem     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101119673     Medline TA:  Curr Top Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departamento de Síntese de Fármacos, Instituto de Tecnologia em Fármacos (Farmanguinhos), FIOCRUZ, Rua Sizenando Nabuco, 100, Manguinhos, Rio de Janeiro - RJ, 21041-250, Brazil. mmacedo@far.fiocruz.br.
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