Document Detail

Fluoride concentrations in plaque, whole saliva, and ductal saliva after application of home-use topical fluorides [published eerratum appears in J Dent Res 1993 Jan;72(1):87]
MedLine Citation:
PMID:  1401438     Owner:  NLM     Status:  MEDLINE    
It is now well-accepted that the primary anti-caries activity of fluoride (F) is via topical action. The retention of F in the mouth after topical fluoride treatment is considered to be an important factor in the clinical efficacy of F. The purpose of this study was to evaluate F levels in ductal saliva, whole saliva, and pooled plaque after treatment with topical F agents intended for home use. Ten consenting adults, mean (SD) age 31.0 (8.2) years, participated in all aspects of the study. Two days before each test, subjects received a professional tooth cleaning and subsequently abstained from all oral hygiene procedures to permit plaque to accumulate, and from the use of F-containing dental products. Treatments consisted of a placebo dentifrice (PD), fluoride dentifrice (FD; 0.24% NaF), fluoride rinse (FR; 0.05% NaF), and fluoride gel (FG; 1.1% NaF). Unstimulated whole saliva and pooled plaque were sampled at multiple points over a 24-hour period. In a separate experimental series, stimulated parotid saliva was sampled over a two-hour period after treatment. Fluoride levels generally followed the same pattern in whole saliva and pooled plaque samples, with FG > FR > FD > PD. Night-time F application resulted in prolonged F retention in whole saliva but not in plaque. Fluoride levels in parotid saliva were only slightly higher after F treatment and returned to baseline levels within two h. The results of this study indicate that the method of F delivery, the F concentration of the agent, and the time of application (daytime vs. night-time) are important factors influencing F levels in the mouth.(ABSTRACT TRUNCATED AT 250 WORDS)
D T Zero; R F Raubertas; J Fu; A M Pedersen; A L Hayes; J D Featherstone
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of dental research     Volume:  71     ISSN:  0022-0345     ISO Abbreviation:  J. Dent. Res.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-11-25     Completed Date:  1992-11-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1768-75     Citation Subset:  D; IM    
Department of Oral Sciences, Eastman Dental Center, Rochester, New York 14620.
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MeSH Terms
Circadian Rhythm
Dental Plaque / chemistry*
Fluorides, Topical / analysis,  pharmacokinetics*
Linear Models
Middle Aged
Oral Hygiene / methods
Saliva / chemistry*,  secretion
Secretory Rate
Grant Support
Reg. No./Substance:
0/Dentifrices; 0/Fluorides, Topical; 0/Gels; 0/Mouthwashes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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