Document Detail

Fluoride concentration in dentin of exfoliated primary teeth as a biomarker for cumulative fluoride exposure.
MedLine Citation:
PMID:  18832828     Owner:  NLM     Status:  MEDLINE    
A biomarker for lifetime fluoride exposure would facilitate population-based research and policy making but currently does not exist. This study examined the suitability of primary tooth dentin as a biomarker by comparing dentin fluoride concentration and fluoride exposures. Ninety-nine children's exfoliated primary teeth were collected from 2 fluoridated and 2 fluoride-deficient communities in North Carolina. Coronal dentin was isolated by microdissection and fluoride concentration assayed using the microdiffusion, ion-specific electrode technique. Information on children's fluoride exposures since birth from drinking water, toothpaste, supplements, rinses, food and beverages was collected by a self-reported questionnaire administered to caregivers. Only a small portion of the variance (10%) in incisor dentin fluoride (mean 792, SD 402 mg/kg) was accounted for by the best linear regression model as evaluated by the adjusted R(2). A moderate portion of the variance (60%) of molar dentin fluoride (mean 768, SD 489 mg/kg) was predicted by dietary fluoride supplement exposures, community of residence, and frequent tea consumption. Results for molars suggest that primary tooth dentin concentration may prove to be a satisfactory biomarker for fluoride exposure.
G G dela Cruz; R G Rozier; J W Bawden
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-10-03
Journal Detail:
Title:  Caries research     Volume:  42     ISSN:  1421-976X     ISO Abbreviation:  Caries Res.     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-03-03     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0103374     Medline TA:  Caries Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  419-28     Citation Subset:  D; IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
Office of the Army Surgeon General, Falls Church, VA 22041-3258, USA.
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MeSH Terms
Biological Markers / analysis
Cariostatic Agents / administration & dosage,  analysis*
Child, Preschool
Dentin / chemistry*
Dietary Supplements
Environmental Exposure*
Fluorides / administration & dosage,  analysis*
Incisor / chemistry
Ion-Selective Electrodes
Molar / chemistry
Mouthwashes / administration & dosage
North Carolina
Tooth Exfoliation*
Tooth, Deciduous / chemistry*
Toothpastes / administration & dosage
Water Supply / analysis
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Cariostatic Agents; 0/Fluorides; 0/Mouthwashes; 0/Tea; 0/Toothpastes

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