| Fluoride and casein phosphopeptide-amorphous calcium phosphate. | |
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MedLine Citation:
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PMID: 18362316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slows the progression of caries and remineralizes enamel subsurface lesions. The aim of this study was to determine the ability of CPP-ACP to increase the incorporation of fluoride into plaque and to promote enamel remineralization in situ. Randomized, double-blind, cross-over studies involved mouthrinses and dentifrices containing CPP-ACP and fluoride. The mouthrinses were used for 60 sec, three times/day for 5 days, and supragingival plaque was collected and analyzed for F. The dentifrices were rinsed as a water slurry for 60 sec four times/day for 14 days in an in situ model. The addition of 2% CPP-ACP to the 450-ppm-F mouthrinse significantly increased the incorporation of fluoride into plaque. The dentifrice containing 2% CPP-ACP produced a level of remineralization similar to that achieved with a dentifrice containing 2800 ppm F. The dentifrice containing 2% CPP-ACP plus 1100 ppm F was superior to all other formulations. |
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Authors:
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E C Reynolds; F Cai; N J Cochrane; P Shen; G D Walker; M V Morgan; C Reynolds |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of dental research Volume: 87 ISSN: 0022-0345 ISO Abbreviation: J. Dent. Res. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-25 Completed Date: 2008-05-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0354343 Medline TA: J Dent Res Country: United States |
Other Details:
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Languages: eng Pagination: 344-8 Citation Subset: D; IM |
Affiliation:
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Cooperative Research Centre for Oral Health Science, School of Dental Science, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Victoria 3000, Australia. e.reynolds@unimelb.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apatites / analysis Cariostatic Agents / administration & dosage, pharmacokinetics, therapeutic use* Caseins / administration & dosage, therapeutic use* Chemistry, Pharmaceutical Cross-Over Studies Dental Enamel / metabolism Dental Plaque / metabolism Dentifrices / therapeutic use Double-Blind Method Drug Combinations Electron Probe Microanalysis Female Fluorides / administration & dosage, pharmacokinetics, therapeutic use* Humans Male Middle Aged Mouthwashes / therapeutic use Placebos Sodium Fluoride / administration & dosage, therapeutic use Tooth Remineralization / methods* |
| Chemical | |
Reg. No./Substance:
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0/Apatites; 0/Cariostatic Agents; 0/Caseins; 0/Dentifrices; 0/Drug Combinations; 0/Fluorides; 0/Mouthwashes; 0/Placebos; 0/casein phosphopeptide-amorphous calcium phosphate nanocomplex; 1306-05-4/fluorapatite; 7681-49-4/Sodium Fluoride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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