Document Detail

Fluoride accumulation and toxicity in laboratory populations of wild small mammals and white mice.
MedLine Citation:
PMID:  8603928     Owner:  NLM     Status:  MEDLINE    
A laboratory experiment was conducted to compare the toxicological response and metabolism of inorganic fluoride by three species of wild mammals and laboratory white mice (Mus musculus L.). The experimental populations of the wild species--the short-tailed field vole (Microtus agrestis L.), the bank vole (Clethrionomys glareolus L.) and the the wood mouse (Apodemus sylvaticus L.)--were laboratory reared from wild stock, and all test animals were exposed to 0, 40 or 80 microgram F per ml in their drinking water for up to 84 days. The 40 and 80 microgram F per ml treatments induced premature mortalities in M. agrestis and C. glareolus only. Differential intakes, absorption and retention of fluoride were evident between M. musculus and M. agrestis, the two species subject to cage studies of fluoride metabolism budgets. Interspecific variation in accumulation of fluoride with time was also evident between all four species as regards the femur, molars and incisors. Severe dental lesions were apparent in species surviving the 80 microgram ml(-1) treatment for 84 days. Overall, however, there were few clear differences in inherent species sensitivity to fluoride, the interspecific variation in metabolism and accumulation rates being attributable mainly to variation in intake.
I C Boulton; J A Cooke; M S Johnson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  15     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:    1995 Nov-Dec
Date Detail:
Created Date:  1996-05-14     Completed Date:  1996-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  423-31     Citation Subset:  IM    
Department of Biology, University of Greenwich, London, UK.
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MeSH Terms
Animals, Laboratory
Animals, Wild
Body Weight / drug effects
Bone and Bones / drug effects,  metabolism
Environmental Pollutants / metabolism*,  toxicity*
Fluorides / metabolism*,  toxicity*
Tooth / drug effects,  metabolism
Reg. No./Substance:
0/Environmental Pollutants; 0/Fluorides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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