Document Detail


Fluorescent probe for detection of bacteria: conformational trigger upon bacterial reduction of an azo bridge.
MedLine Citation:
PMID:  22618019     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Using biomimetic chemical reduction or Clostridium perfringens cell extract containing azoreductase, the dimer-fluorescent probe 2,4-O-bisdansyl-6,7-diazabicyclooct-6-ene, which possesses a conformationally constrained cis-azo bridge, is reduced to the tetra-equatorial 2,4-O-bisdansyl-cyclohexyl-3,5-bisammonium salt which exhibits fluorescence indicative of a dansyl monomer.
Authors:
Nicholas J W Rattray; Waleed A Zalloum; David Mansell; Joe Latimer; Carl H Schwalbe; Alexander J Blake; Elena V Bichenkova; Sally Freeman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-23
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
School of Pharmacy & Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK. sally.freeman@manchester.ac.uk elena.bichenkova@manchester.ac.uk.
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