Document Detail

Fluorescent nanothermometers provide controlled plasmonic-mediated intracellular hyperthermia.
MedLine Citation:
PMID:  23199286     Owner:  NLM     Status:  Publisher    
Aims: This article demonstrates how controlled hyperthermia at the cellular level can be achieved. Methods: The method is based on the simultaneous intracellular incorporation of fluorescence nanothermometers (CdSe quantum dots) and metallic nanoheaters (gold nanorods). Results: Real-time spectral analysis of the quantum dot emission provides a detailed feedback about the intracellular thermal loading caused by gold nanorods excited at the plasmon frequency. Based on this approach, thermal dosimetry is assessed in such a way that the infrared laser (heating) power required to achieve catastrophic intracellular temperature increments in cancer cells is identified. Conclusions: This pure optical method emerges as a new and promising guide for the development of infrared hyperthermia therapies with minimal invasiveness. Original submitted 6 March 2012; Revised submitted 3 July 2012.
Laura Martínez Maestro; Patricia Haro-González; M Carmen Iglesias-de la Cruz; Francisco Sanz-Rodríguez; Angeles Juarranz; José García Solé; Daniel Jaque
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-2
Journal Detail:
Title:  Nanomedicine (London, England)     Volume:  -     ISSN:  1748-6963     ISO Abbreviation:  Nanomedicine (Lond)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278111     Medline TA:  Nanomedicine (Lond)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Fluorescence Imaging Group, Departamento de Física de Materiales, Facultad de Ciencias, Instituto Nicolás Cabrera, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
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