| Fluorescent molecular sensory system based on bis pyrene-modified gamma-cyclodextrin dimer for steroids and endocrine disruptors. | |
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MedLine Citation:
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PMID: 11990613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A gamma-cyclodextrin dimer modified with two pyrene moieties, 6-(2-pyrenebutylate-aminoethyl)pyrenebutylate-amino-6-deoxy-bis-gamma-cyclodextrin, has been synthesized in the presence of N,N'-dicyclohexycarbodiimide from gamma-cyciodextrin dimer linked with ethylenediamine at an upper rim. The sensing ability and binding property of the titled dimer were investigated for bile acids and endocrine disruptors. This cyclodextrin dimer showed both monomer and excimer fluorescence; the guest-induced emissions were observed as increases or decreases depending on the guest. The values deltaI(m)/I0(m) and deltaI(ex)/I0(ex), where I0(m) and I(m) are fluorescence intensities of monomer emission in the absence and presence of a guest and I0(ex) and I(ex) are those of excimer emission and deltaI(m) and deltaI(ex) were I(m) - I0(m) and I(ex) - I0(ex), respectively, were used as a parameter of sensitivity. This host exhibited highly sensitive molecular recognition ability for bile acids and endocrine disruptors, in which the sensing parameters obtained from monomer emission were plus or minus values, whereas the parameters obtained as excimer emission were minus ones. The behavior of the appended moieties of the host during a host-guest complexation was studied by induced circular dichroism (ICD) and fluorescence spectra. The ICD intensities of the titled dimer were decreased upon an addition of a guest. The guest-induced variations in the fluorescence and ICD intensity suggest that the appended moieties move by altering the spatial relationship in the hydrophobic space between two linked cyclodextrins. |
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Authors:
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M Narita; S Mima; N Ogawa; F Hamada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry Volume: 17 ISSN: 0910-6340 ISO Abbreviation: Anal Sci Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2002-05-06 Completed Date: 2002-07-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8511078 Medline TA: Anal Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 379-85 Citation Subset: IM |
Affiliation:
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Department of Materials-process Engineering and Applied Chemistry for Environments, Faculty of Engineering and Resource Science, Akita University, Tegata, Japan. mnarita@ipc.akita-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biosensing Techniques Circular Dichroism Cyclodextrins / chemical synthesis, chemistry* Dimerization Indicators and Reagents / chemical synthesis, metabolism Pyrenes / chemical synthesis, chemistry* Spectrometry, Fluorescence Steroids / chemistry* gamma-Cyclodextrins* |
| Chemical | |
Reg. No./Substance:
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0/6-(2-pyrenebutylate-aminoethyl)pyrenebutylate-amino-6-deoxy-bis-cyclodextrin; 0/Cyclodextrins; 0/Indicators and Reagents; 0/Pyrenes; 0/Steroids; 0/gamma-Cyclodextrins; 17465-86-0/gamma-cyclodextrin |
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