| Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells. | |
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MedLine Citation:
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PMID: 21165468 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by (1)H NMR, mass spectrometry analysis and Gaussian calculations. |
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Authors:
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Mingming Hu; Jiangli Fan; Honglin Li; Kedong Song; Song Wang; Guanghui Cheng; Xiaojun Peng |
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Publication Detail:
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Type: Journal Article Date: 2010-12-16 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: 9 ISSN: 1477-0539 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
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Languages: eng Pagination: 980-3 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China. pengxj@dlut.edu.cn fanjl@dlut.edu.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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