Document Detail


Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells.
MedLine Citation:
PMID:  21165468     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by (1)H NMR, mass spectrometry analysis and Gaussian calculations.
Authors:
Mingming Hu; Jiangli Fan; Honglin Li; Kedong Song; Song Wang; Guanghui Cheng; Xiaojun Peng
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Publication Detail:
Type:  Journal Article     Date:  2010-12-16
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  9     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  980-3     Citation Subset:  IM    
Affiliation:
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China. pengxj@dlut.edu.cn fanjl@dlut.edu.cn.
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