Document Detail

Fluorescent advanced glycation end products in the detection of factual stages of cartilage degeneration.
MedLine Citation:
PMID:  16555949     Owner:  NLM     Status:  MEDLINE    
Patients treated for knee disorders were included in this study. They were examined clinically (Lequesne and Tegner scores) and by standard X-ray investigation. Patients underwent a surgical procedure, either arthroscopy or knee replacement. At the initial phase of surgery, a sample of cartilage was taken for laboratory examination. Progression of the disorder and the clinical examination was correlated with the actual state of the cartilage using a novel fluorescence approach. The intrinsic fluorescence of cartilages was shown as a suitable and sensitive method for detection of the actual state of cartilages because the correlation with X-ray examination and clinical status was found. Intrinsic fluorescence properties of cartilages from patients with chondropathy and osteoarthritis were described and found to be age-dependent. We also observed a higher concentration of advanced glycation end products due to inflammatory and/or degenerative processes in the cartilage. In addition, acute pathological changes due to diseases such as meniscal lesions or anterior cruciate ligament rupture caused a significant increase of formation of advanced glycation end products even in the group of young patients. In fact, such an observation could be crucial and important for the detection of knee conditions suspected of early meniscal and/or ACL lesions especially among young patients.
M Handl; E Filová; M Kubala; Z Lánský; L Kolácná; J Vorlícek; T Trc; M Pach; E Amler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-23
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  56     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-17     Completed Date:  2007-08-01     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  235-42     Citation Subset:  IM    
Orthopedic Clinic, Second Faculty of Medicine, Charles University in Prague, Czech Republic.
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MeSH Terms
Age Distribution
Age Factors
Aged, 80 and over
Arthroplasty, Replacement, Knee
Cartilage Diseases / diagnosis*,  metabolism,  radiography,  surgery
Cartilage, Articular / metabolism*,  radiography,  surgery
Glycosylation End Products, Advanced / metabolism*
Joint Diseases / diagnosis*,  metabolism,  radiography,  surgery
Knee Injuries / diagnosis*,  metabolism,  radiography,  surgery
Knee Joint / metabolism*,  radiography,  surgery
Middle Aged
Osteoarthritis, Knee / diagnosis,  metabolism
Predictive Value of Tests
Sensitivity and Specificity
Severity of Illness Index
Spectrometry, Fluorescence*
Synovitis / diagnosis,  metabolism
Reg. No./Substance:
0/Glycosylation End Products, Advanced

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