Document Detail

Fluorescence microscopic analysis of bone osseointegration of strontium-substituted hydroxyapatite implants.
MedLine Citation:
PMID:  22556174     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to analyze the effect of strontium-substituted hydroxyapatite (Sr-HA) on bone osseointegration of the implants using fluorescence microscopy. We allocated 20 implants to two groups: Sr-HA group and HA group. Electrochemically deposited HA and Sr-HA coatings were applied onto the implants separately. All the implants were inserted into femur bone of rabbits. Oxytetracycline hydrochloride, alizarin-complexon, and calcein green were respectively administered 7, 28, and 46 d after the implantation. After eight weeks, femurs were retrieved and prepared for the fluorescence microscopy observation. We analyzed the bone mineral apposition rates (MARs), bone area ratios (BARs), and bone to implant contact (BIC) of the two groups. Fluorescence microscopic observation showed that all groups exhibited extensive early peri-implant bone formation. The MAR of the Sr-HA group was greater than that for pure HA from 7 to 28 d after implantation, but no significant difference was found at later stage. And the BIC showed difference at 7 and 28 d compared with pure HA. We concluded that Sr-HA coating can improve the bone osseointegration of the implant in the early stage compared with the HA coating.
Dan-li Fu; Qiao-hong Jiang; Fu-ming He; Guo-li Yang; Li Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  13     ISSN:  1862-1783     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-04     Completed Date:  2012-09-10     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  364-71     Citation Subset:  IM    
Department of General Dentistry, Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
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MeSH Terms
Bone Screws*
Bone Substitutes / administration & dosage*,  chemistry
Coated Materials, Biocompatible / administration & dosage,  chemistry
Durapatite / administration & dosage*,  chemistry
Femur / drug effects*,  pathology*,  surgery
Microscopy, Fluorescence
Osseointegration / drug effects,  physiology*
Strontium / administration & dosage*,  chemistry
Reg. No./Substance:
0/Bone Substitutes; 0/Coated Materials, Biocompatible; 1306-06-5/Durapatite; 7440-24-6/Strontium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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