Document Detail

Fluorescence lifetime measurements of disulfonated aluminium phthalocyanine in the presence of microbial cells.
MedLine Citation:
PMID:  12856705     Owner:  NLM     Status:  MEDLINE    
The fluorescence lifetimes of disulfonated aluminium phthalocyanine (AlPcS2) in the presence of several different microbial cells are measured using the technique of time correlated single photon counting (TCSPC) employing front-face illumination. The microbes studied are: Escherichia coli, Porphyromonas gingivalis (Gram-negative bacteria), Streptococcus mutans (a Gram-positive bacterium), and the yeast Candida albicans. Complex fluorescence decays are observed when AlPcS2 is in the presence of these microbes; the fluorescence decay data can be fitted to a distribution of exponential lifetimes indicating that the AlPcS2 molecules experience a range of micro-environments The average fluorescence lifetimes of AlPcS2 in the presence of the microbes studied range from 4.85 to 5.95 ns, indicating differences in the cellular localisation of AlPcS2 with each of the microbes studied. These novel data are presented alongside a brief summary of existing AlPcS2 fluorescence lifetime data measured both in solution and in model biological systems.
Jackie A Lacey; David Phillips
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology     Volume:  1     ISSN:  1474-905X     ISO Abbreviation:  Photochem. Photobiol. Sci.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2003-07-14     Completed Date:  2003-08-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101124451     Medline TA:  Photochem Photobiol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  378-83     Citation Subset:  IM    
Department of Chemistry, Imperial College of Science, Technology and Medicine, London, UK.
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MeSH Terms
Candida albicans*
Escherichia coli*
Indoles / chemistry,  metabolism*
Organometallic Compounds / chemistry,  metabolism*
Porphyromonas gingivalis*
Streptococcus mutans*
Reg. No./Substance:
0/Indoles; 0/Organometallic Compounds; 0/Solutions; 68637-19-4/aluminum phthalocyanine disulfonate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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