| Fluorescence in situ hybridization dissection of a chronic myeloid leukemia case bearing the apparently balanced translocations (9;22)(q34;q11.2) and (11;11)(p15;q13). | |
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MedLine Citation:
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PMID: 19061779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report on a patient with chronic myeloid leukemia (CML), which was detected by conventional cytogenetic analysis, to carry two different acquired and apparently balanced translocations, (9;22)(q34;q11.2) and (11;11)(p15;q13). By fluorescence in situ hybridization characterization, we were able to finely map the genomic regions involved in the translocation breakpoints and to disclose concomitant deletions adjacent to the breakpoints on the two derivative chromosomes 11 and the derivative chromosome 22, and the insertion of a segment from chromosome band 11q12.2 into the derivative chromosome 9. We discuss the putative mechanism that could have led to the formation of this complex rearrangement and speculate on the role in leukemogenesis played by the genes mapping at the breakpoints and within the deleted regions. |
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Authors:
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Francesca Malvestiti; Daniela Colombo; Daniele Perego; Ornella Rodeschini; Palma Finelli; Lidia Larizza; Daniela Giardino |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 188 ISSN: 1873-4456 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: United States |
Other Details:
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Languages: eng Pagination: 42-7 Citation Subset: IM |
Affiliation:
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Laboratory of Medical Cytogenetics and Molecular Genetics, Istituto Auxologico Italiano, Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Agents / therapeutic use Bone Marrow Cells Chromosome Deletion Chromosome Mapping / methods Chromosome Painting* Chromosomes, Human, Pair 11 / genetics* Chromosomes, Human, Pair 22 / genetics* Chromosomes, Human, Pair 9 / genetics* Gene Rearrangement Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis, drug therapy, genetics* Male Philadelphia Chromosome Piperazines / therapeutic use Pyrimidines / therapeutic use Translocation, Genetic* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Piperazines; 0/Pyrimidines; 152459-95-5/imatinib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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