Document Detail

Fluorescence diagnostics as a guide for demarcation and biopsy of suspected anal cancer.
MedLine Citation:
PMID:  22182375     Owner:  NLM     Status:  In-Data-Review    
Background  Malignant epithelial tumors of the perianal skin are relatively rare however show high recurrence rates. A preoperative precise diagnosis and demarcation of the involved cancerous skin remains challenging but is worthwhile to minimize tissue defects and possible limitations of quality of life. Objectives  To show the use of fluorescence diagnostics (FD) in the management of chronic perianal disease. Methods  FD was performed using methylaminolevulinate (MAL) for three hours topically followed by visualization with blue light (405 nm). Results  We report on two patients in whom FD helped to demarcate the involved tissue or to direct biopsy to ascertain the final diagnosis. In one patient with a history of Bowen's disease and recurrent anal carcinoma, biopsy showed extramammary Paget's disease and thus was treated by surgical anoplasty. The other patient had a history of chronic anal eczema, and FD-directed biopsy could exclude suspected malignancy so that the anal eczema was treated by local therapy. Conclusions  FD is a non-invasive technique which can be used in the perianal region in order to delineate pathologic processes which may reduce the number of surgical interventions.
Martin Kriz; Juraj Hegyi; Thomas Ruzicka; Carola Berking
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  51     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-4     Citation Subset:  IM    
Copyright Information:
© 2012 The International Society of Dermatology.
Department of Dermatology and Allergology, Ludwig-Maximilian University, Munich, Germany.
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