Document Detail

Fluorescein angiography and retinal vascular development in premature infants.
MedLine Citation:
PMID:  23016619     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the role of fluorescein angiography (FA) in the management of retinopathy of prematurity (ROP) in preterm newborns.
METHODS: An observational case series of 13 extremely low birth weight infants. From September 2009 to March 2010, 13 newborn infants with a gestational age <29 weeks end/or birth weight <1000 g underwent serial fluorescein angiography with RetCam (Clarity, Pleasanton, CA) every 2 weeks. The fluorescein angiograms were examined to optimize the timing of diagnosis of ROP and to investigate development of retinal and choroidal vascularization.
RESULTS: There were no side effects related to FA. Variable features of retinal and choroidal circulation in preterm infants with a high risk of developing ROP were noted. FA allows vessels branching at the junction between vascular and avascular retina (V-Av junction) to be viewed easily and shows the ROP findings that sometimes cannot be seen by indirect ophthalmoscopy. Dye leakage is the most significant sign of progression to severe ROP or the need for surgery in newborn babies with ROP.
CONCLUSIONS: RetCam-assisted intravenous FA is safe and allows a more objective assessment of the ROP stage and zone.
Velia Purcaro; Purcaro Velia; Antonio Baldascino; Baldascino Antonio; Patrizia Papacci; Papacci Patrizia; Carmen Giannantonio; Giannantonio Carmen; Anna Molisso; Molisso Anna; Fernando Molle; Molle Fernando; Domenico Lepore; Lepore Domenico; Costantino Romagnoli; Romagnoli Costantino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25 Suppl 3     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2013-04-03     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  IM    
Department of Paediatrics, Division of Neonatology, Catholic University of Rome, Rome, Italy.
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MeSH Terms
Choroid / blood supply
Fluorescein Angiography*
Infant, Newborn
Infant, Premature
Retinal Vessels / embryology
Retinopathy of Prematurity / diagnosis*,  embryology
Erratum In:
J Matern Fetal Neonatal Med. 2013 Oct;26(15):1563
Note: Velia, Purcaro [corrected to Purcaro, Velia]; Antonio, Baldascino [corrected to Baldascino, Antonio]; Patrizia, Papacci [corrected to Papacci, Patrizia]; Carmen, Giannantonio [corrected to Giannantonio, Carmen]; Anna, Molisso [corrected to Molisso, Anna]; Fernando, Molle [corrected to Molle, Fernando]; Domenico, Lepore [corrected to Lepore, Domenico]; Costantino, Romagnoli [corrected to Romagnoli, Costantino]

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