| (+)-Fluorenylethylchloroformate (FLEC) - improved synthesis for application in chiral analysis and peptidomimetic synthesis. | |
MedLine Citation:
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PMID: 23483118 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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An efficient synthesis of the enantiomers of fluorenylethylchloroformate (FLEC) has been achieved that allows the routine application of the reagent for the resolution of chiral amines including unusual amino acids. The utility of the fluorenylethoxycarbonyl (Feoc) group as a chiral Fmoc equivalent, for combined resolution and protection of amino acids, in solid phase peptide synthesis is also shown. |
Authors:
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Michelle A Camerino; David K Chalmers; Philip E Thompson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-3-12 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: - ISSN: 1477-0539 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-3-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia. Philip.thompson@monash.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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