Document Detail

Fluor-hydroxyapatite sol-gel coating on titanium substrate for hard tissue implants.
MedLine Citation:
PMID:  15020107     Owner:  NLM     Status:  MEDLINE    
Hydroxyapatite (HA) and fluor-hydroxyapatite (FHA) films were deposited on a titanium substrate using a sol-gel technique. Different concentrations of F- were incorporated into the apatite structure during the sol preparation. Typical apatite structures were obtained for all coatings after dipping and subsequent heat treatment at 500 degrees C. The films obtained were uniform and dense, with a thickness of approximately 5 microm. The dissolution rate of the coating layer decreased with increasing F- incorporation within the apatite structure, which demonstrates the possibility of tailoring the solubility by a functional gradient coating of HA and FHA. The cell proliferation rate on the coating layer decreased slightly with increasing F- incorporation. The alkaline phosphatase (ALP) activity of the cells on all the HA and FHA coated samples showed much higher expression levels compared to pure Ti. This confirmed the improved activity of cell functions on the substrates with the sol-gel coating treatment.
Hae-Won Kim; Hyoun-Ee Kim; Jonathan C Knowles
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Biomaterials     Volume:  25     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-03-15     Completed Date:  2004-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  3351-8     Citation Subset:  IM    
School of Materials Science and Engineering, Seoul National University, Seoul 151-742, South Korea.
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MeSH Terms
Biocompatible Materials / chemistry*
Body Fluids / chemistry
Bone Substitutes / chemistry*
Cell Differentiation / physiology
Cell Division
Cell Line
Cell Survival
Hydroxyapatites / chemistry*
Implants, Experimental*
Materials Testing
Molecular Conformation
Osteoblasts / cytology*,  physiology*
Phase Transition
Surface Properties
Titanium / chemistry*
Reg. No./Substance:
0/Biocompatible Materials; 0/Bone Substitutes; 0/Hydroxyapatites; 55575-17-2/fluor-hydroxylapatite; 7440-32-6/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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