Document Detail


Flunarizine: a possible adjuvant medication against soman poisoning?
MedLine Citation:
PMID:  15478944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Organophosphate (OP) nerve agents are amongst the most toxic chemicals. One of them, soman, can induce severe epileptic seizures and brain damage for which therapy is incomplete. The present study shows that pretreatment with flunarizine (Flu), a voltage-dependent calcium channel blocker, when used alone, does not produce any beneficial effect against the convulsions, neuropathology and lethality induced by soman. Flu was also tested in combination with atropine sulfate and diazepam. In this case, although only some results reach statistical significance, an encouraging general trend toward an improvement of the anticonvulsant, neuroprotective and antilethal capacities of this classical anti-OP two-drug regimen is constantly observed. In the light of these findings, it seems premature to definitely reject (or recommend) Flu as a possible adjuvant medication against soman poisoning. Further studies are required to determine its real potential interest.
Authors:
Pierre Carpentier; Annie Foquin; Guy Lallement; Fréderic Dorandeu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  27     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-10-13     Completed Date:  2005-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-31     Citation Subset:  IM    
Affiliation:
Centre de Recherches du Service de Santé des Armées, Unité de Neuropharmacologie, La Tronche Cedex, France. pierrecarpentier@crssa.net
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / therapeutic use
Brain / pathology
Calcium Channel Blockers / therapeutic use*
Chemical Warfare Agents / toxicity*
Diazepam / therapeutic use
Drug Therapy, Combination
Flunarizine / therapeutic use*
GABA Modulators / therapeutic use
Lethal Dose 50
Male
Muscarinic Antagonists / therapeutic use
Rats
Rats, Wistar
Seizures / chemically induced,  prevention & control
Soman / antagonists & inhibitors,  toxicity*
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Chemical Warfare Agents; 0/GABA Modulators; 0/Muscarinic Antagonists; 439-14-5/Diazepam; 51-55-8/Atropine; 52468-60-7/Flunarizine; 96-64-0/Soman

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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