| Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient. | |
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MedLine Citation:
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PMID: 8111944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this report is to describe the use of flumazenil as a diagnostic aid in the differential diagnosis of coma in a patient with an inadvertent overdose of benzodiazepines. We report a patient with suspected septic encephalopathy whose level of consciousness markedly improved following flumazenil administration. Subsequent analysis revealed the presence of benzodiazepines and their metabolites in the blood and urine although the patient had not received benzodiazepines for over two weeks. The critically ill patient with multiorgan failure may have considerable derangement of benzodiazepine metabolism; therefore, if an obtunded patient's level of consciousness improves following flumazenil administration, benzodiazepine intoxication must be considered. |
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Authors:
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H Sprenger; M D Sharpe; R S McLachlan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Canadian journal of anaesthesia = Journal canadien d'anesthésie Volume: 41 ISSN: 0832-610X ISO Abbreviation: Can J Anaesth Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-03-31 Completed Date: 1994-03-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8701709 Medline TA: Can J Anaesth Country: CANADA |
Other Details:
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Languages: eng Pagination: 52-5 Citation Subset: IM |
Affiliation:
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W.E. Spoerel Intensive Care Unit, University Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bacterial Infections / diagnosis Coma / chemically induced*, diagnosis* Critical Illness* Diagnosis, Differential Diazepam / blood, poisoning* Flumazenil / diagnostic use* Hepatic Encephalopathy / diagnosis Humans Lorazepam / poisoning Male Midazolam / poisoning |
| Chemical | |
Reg. No./Substance:
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439-14-5/Diazepam; 59467-70-8/Midazolam; 78755-81-4/Flumazenil; 846-49-1/Lorazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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