Document Detail

Fluid therapy in septic shock.
MedLine Citation:
PMID:  20601867     Owner:  NLM     Status:  In-Process    
PURPOSE OF REVIEW: To examine the role of fluid therapy in the pathogenesis of severe sepsis and septic shock. The type, composition, titration, management strategies and complications of fluid administration will be examined in respect to outcomes.
RECENT FINDINGS: Fluids have a critical role in the pathogenesis and treatment of early resuscitation of severe sepsis and septic shock.
SUMMARY: Although this pathogenesis is evolving, early titrated fluid administration modulates inflammation, improves microvascular perfusion, impacts organ function and outcome. Fluid administration has limited impact on tissue perfusion during the later stages of sepsis and excess fluid is deleterious to outcome. The type of fluid solution does not seem to influence these observations.
Emanuel P Rivers; Anja Kathrin Jaehne; Laura Eichhorn-Wharry; Samantha Brown; David Amponsah
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in critical care     Volume:  16     ISSN:  1531-7072     ISO Abbreviation:  Curr Opin Crit Care     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504454     Medline TA:  Curr Opin Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297-308     Citation Subset:  IM    
Department of Emergency Medicine, Henry Ford Hospital, Wayne State University, Detroit, Michigan, USA.
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