Document Detail

Fluid resuscitation with hypertonic saline in endotoxic shock.
MedLine Citation:
PMID:  3791579     Owner:  NLM     Status:  MEDLINE    
Hypertonic saline has been used in the treatment of hypovolemic or burn shock for its rapid volemic effects. Hypertonic solutions could also improve cardiac performance and protect cellular metabolism in acute circulatory failure. We therefore studied the hemodynamic effects of continuous hypertonic saline infusion in the treatment of severe endotoxic shock in the dog. Thirty minutes after slow injection of 3 mg/kg of Escherichia coli endotoxin, fluid resuscitation with either hypertonic saline containing 1,200 mOsm of NaCl/liter (eight dogs) or normotonic saline solution (eight dogs) was started and titrated to maintain left-sided filling pressures at control level. For the next 210 min, the total amount of fluid administered was 64.5 +/- 7.8 ml/kg in the hypertonic group and 83.6 +/- 10.3 ml/kg in the normotonic group. These differences were not statistically significant. Intravascular pressures were similar in the two groups, but cardiac output, stroke volume, and oxygen consumption were significantly higher in the hypertonic group. These results therefore indicate that hypertonic saline can rapidly restore oxygen transport and tissue oxygen consumption in septic shock. The duration of these hemodynamic effects, however, remains to be determined.
P Luypaert; J L Vincent; M Domb; P Van der Linden; S Blecic; G Azimi; A Bernard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulatory shock     Volume:  20     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1986  
Date Detail:
Created Date:  1987-02-19     Completed Date:  1987-02-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  311-20     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Cardiac Output
Fluid Therapy*
Oxygen Consumption
Saline Solution, Hypertonic / therapeutic use*
Shock, Septic / metabolism,  physiopathology,  therapy*
Sodium Chloride / therapeutic use*
Stroke Volume
Reg. No./Substance:
0/Saline Solution, Hypertonic; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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