| Fluid replacement in dengue shock syndrome: a randomized, double-blind comparison of four intravenous-fluid regimens. | |
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MedLine Citation:
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PMID: 10589889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dengue hemorrhagic fever and dengue shock syndrome (DSS) are major causes of childhood morbidity and mortality in many tropical countries. Increased intravascular permeability leading to shock is the cardinal feature of DSS. Fluid resuscitation to counteract massive plasma leakage is the mainstay of treatment. A double-blind, randomized trial comparing four intravenous-fluid regimens for acute resuscitation of 50 children with DSS was conducted. Colloids (dextran 70 or the protein digest gelafundin 35,000) restored cardiac index and blood pressure and normalized hematocrit more rapidly than crystalloids (Ringer's lactate or 0.9%-weight/volume saline). Dextran 70 provided the most rapid normalization of the hematocrit and restoration of the cardiac index, without adverse effects, and may be the preferred solution for acute resuscitation in DSS. Further large-scale double-blind trials are required to provide an evidence-based approach to the management of DSS. |
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Authors:
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N M Dung; N P Day; D T Tam; H T Loan; H T Chau; L N Minh; T V Diet; D B Bethell; R Kneen; T T Hien; N J White; J J Farrar |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 29 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-12-16 Completed Date: 1999-12-16 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 787-94 Citation Subset: IM |
Affiliation:
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The Centre for Tropical Diseases and the Wellcome Trust Clinical Research Unit, Ho Chi Minh City, Vietnam. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Dengue Hemorrhagic Fever / blood, therapy* Dextrans / therapeutic use Double-Blind Method Female Fluid Therapy* Hematocrit Humans Isotonic Solutions / therapeutic use Male Resuscitation* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Isotonic Solutions; 8022-63-7/Ringer's lactate; 9004-54-0/Dextrans |
| Comments/Corrections | |
Comment In:
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Clin Infect Dis. 1999 Oct;29(4):795-6
[PMID:
10589890
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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