Document Detail

Fluid replacement following dehydration reduces oxidative stress during recovery.
MedLine Citation:
PMID:  19344695     Owner:  NLM     Status:  MEDLINE    
To investigate the effects of hydration status on oxidative DNA damage and exercise performance, 10 subjects ran on a treadmill until exhaustion at 80% VO(2max) during four different trials [control (C), 3% dehydration (D), 3% dehydration+water (W) or 3% dehydration+sports drink (S)]. Dehydration significantly decreased exercise time to exhaustion (D<C and S). Plasma MDA levels were significantly higher at pre-exercise in D than C. Plasma TAS was significantly lower at pre-exercise in C and S than in D, and was significantly lower in S than D at 60min of recovery. Dehydration significantly increased oxidative DNA damage during exercise, but fluid replacement with water or sports drink alleviated it equally. These results suggest that (1) dehydration impairs exercise performance and increases DNA damage during exercise to exhaustion; and (2) fluid replacement prolongs exercise endurance and attenuates DNA damage.
Il-Young Paik; Myung-Hyun Jeong; Hwa-Eun Jin; Young-Il Kim; Ah-Ram Suh; Su-Youn Cho; Hee-Tae Roh; Chan-Ho Jin; Sang-Hoon Suh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-01
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  383     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-27     Completed Date:  2009-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-7     Citation Subset:  IM    
Department of Physical Education, Yonsei University, Shinchon-Dong, Seodaemun-Gu, Seoul, South Korea.
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MeSH Terms
Antioxidants / analysis
DNA Damage / drug effects
Dehydration / blood,  physiopathology*
Lymphocytes / drug effects,  metabolism
Malondialdehyde / blood
Oxidative Stress / drug effects*
Water / administration & dosage*
Young Adult
Reg. No./Substance:
0/Antioxidants; 542-78-9/Malondialdehyde; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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