Document Detail

Fluid reabsorption by Necturus proximal tubule perfused with solutions of normal and reduced osmolarity.
MedLine Citation:
PMID:  6127715     Owner:  NLM     Status:  MEDLINE    
Fluid absorption in Necturus proximal tubule was studied when the kidneys were perfused with solutions of different osmolarities. The rate of fluid absorption was inversely proportional to the perfusion fluid osmolarity, while Na uptake remained constant. No difference was detected between the collected and injected luminal fluid, i.e. reabsorption was isotonic at normal and reduced osmolarities. The transtubular osmotic permeability remained fairly constant under the different perfusion osmolarities. Using our experimental results to test various models based on osmotic equilibration across the tubule wall we show that none of these provides an adequate mechanism for fluid absorption in this epithelium.
G Whittembury; B S Hill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain)     Volume:  215     ISSN:  0080-4649     ISO Abbreviation:  Proc. R. Soc. Lond., B, Biol. Sci.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-21     Completed Date:  1982-12-21     Revised Date:  2007-04-30    
Medline Journal Info:
Nlm Unique ID:  7505889     Medline TA:  Proc R Soc Lond B Biol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  411-31     Citation Subset:  IM    
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MeSH Terms
Kidney Tubules, Proximal / physiology*,  ultrastructure
Microscopy, Electron
Osmolar Concentration
Sodium / metabolism
Water-Electrolyte Balance*
Reg. No./Substance:

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