Document Detail


Fluid pressure and flow as a cause of bone resorption.
MedLine Citation:
PMID:  20718695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Unstable implants in bone become surrounded by an osteolytic zone. This is seen around loose screws, for example, but may also contribute to prosthetic loosening. Previous animal studies have shown that such zones can be induced by fluctuations in fluid pressure or flow, caused by implant instability.
METHOD: To understand the roles of pressure and flow, we describe the 3-dimensional distribution of osteolytic lesions in response to fluid pressure and flow in a previously reported rat model of aseptic loosening. 50 rats had a piston inserted in the proximal tibia, designed to produce 20 local spikes in fluid pressure of a clinically relevant magnitude (700 mmHg) twice a day. The spikes lasted for about 0.3 seconds. After 2 weeks, the pressure was measured in vivo, and the osteolytic lesions induced were studied using micro-CT scans.
RESULTS: Most bone resorption occurred at pre-existing cavities within the bone in the periphery around the pressurized region, and not under the piston. This region is likely to have a higher fluid flow and less pressure than the area just beneath the piston. The velocity of fluid flow was estimated to be very high (roughly 20 mm/s).
INTERPRETATION: The localization of the resorptive lesions suggests that high-velocity fluid flow is important for bone resorption induced by instability.
Authors:
Anna Fahlgren; Mathias P G Bostrom; Xu Yang; Lars Johansson; Ulf Edlund; Fredrik Agholme; Per Aspenberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta orthopaedica     Volume:  81     ISSN:  1745-3682     ISO Abbreviation:  Acta Orthop     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-19     Completed Date:  2010-09-09     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101231512     Medline TA:  Acta Orthop     Country:  England    
Other Details:
Languages:  eng     Pagination:  508-16     Citation Subset:  IM    
Affiliation:
Division of Orthopaedics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. Anna.Fahlgren@liu.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Fluids*
Bone Resorption / etiology*,  physiopathology
Disease Models, Animal
Hydrostatic Pressure / adverse effects
Osteolysis / etiology,  physiopathology
Prosthesis Failure*
Rats
Rheology
Tibia / pathology,  physiopathology*
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