Document Detail

Fluid loss does not explain coagulation activation during air travel.
MedLine Citation:
PMID:  18521508     Owner:  NLM     Status:  MEDLINE    
The mechanism of air travel-related venous thrombosis is unclear. Although immobility plays a pivotal role, other factors such as fluid loss may contribute. We investigated whether fluid loss occurred more in individuals with coagulation activation after air travel than in subjects without. As a secondary aim, we investigated whether fluid loss per se occurred during air travel. In this crossover study, 71 healthy volunteers were exposed to eight hours of air travel, eight hours immobilization in a cinema, and a daily-life control situation. Markers of fluid loss (haematocrit, serum osmolality and albumin) and of coagulation activation were measured before and after each exposure. The study included 11 volunteers with and 55 volunteers without coagulation activation during the flight. The change in parameters of fluid loss was not different in volunteers with an activated clotting system from those without (difference between groups in haematocrit: -0.6%, 95% confidence interval [CI]: -1.9 to 0.6). On a group level, mean haematocrit values decreased during all three exposures. However, in some individuals it increased, which occurred in more participants during the flight (34%; 95% CI 22 to 46) than during the daily-life situation (19%; 95% CI 10 to 28). These findings do not support the hypothesis that fluid loss contributes to thrombus formation during air travel.
Anja J M Schreijer; Suzanne C Cannegieter; Marianna Caramella; Joost C M Meijers; Raymond T Krediet; Ries M Simons; Frits R Rosendaal
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  99     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1053-9     Citation Subset:  IM    
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
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MeSH Terms
Activities of Daily Living
Antithrombin III
Blood Coagulation*
Cross-Over Studies
Dehydration / blood,  complications*,  etiology,  physiopathology
Fibrin Fibrinogen Degradation Products / metabolism
Immobilization / adverse effects
Osmolar Concentration
Peptide Fragments / blood
Peptide Hydrolases / blood
Risk Factors
Serum Albumin / metabolism
Venous Thrombosis / blood*,  etiology,  physiopathology
Water-Electrolyte Balance*
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/Serum Albumin; 0/antithrombin III-protease complex; 0/fibrin fragment D; 0/prothrombin fragment 1.2; 9000-94-6/Antithrombin III; 9001-26-7/Prothrombin; EC 3.4.-/Peptide Hydrolases
Comment In:
Thromb Haemost. 2008 Jun;99(6):985-6   [PMID:  18521494 ]

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