Document Detail


Fluid flows and forces in development: functions, features and biophysical principles.
MedLine Citation:
PMID:  22395739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Throughout morphogenesis, cells experience intracellular tensile and contractile forces on microscopic scales. Cells also experience extracellular forces, such as static forces mediated by the extracellular matrix and forces resulting from microscopic fluid flow. Although the biological ramifications of static forces have received much attention, little is known about the roles of fluid flows and forces during embryogenesis. Here, we focus on the microfluidic forces generated by cilia-driven fluid flow and heart-driven hemodynamics, as well as on the signaling pathways involved in flow sensing. We discuss recent studies that describe the functions and the biomechanical features of these fluid flows. These insights suggest that biological flow determines many aspects of cell behavior and identity through a specific set of physical stimuli and signaling pathways.
Authors:
Jonathan B Freund; Jacky G Goetz; Kent L Hill; Julien Vermot
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  139     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-07     Completed Date:  2012-05-04     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  1229-45     Citation Subset:  IM    
Affiliation:
University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Biophysics / methods*
Cilia / physiology
Developmental Biology / methods*
Endothelial Cells / cytology
Humans
Models, Biological
Morphogenesis
Signal Transduction
Stress, Mechanical
Tensile Strength
Zebrafish
Grant Support
ID/Acronym/Agency:
R01AI052348/AI/NIAID NIH HHS
Comments/Corrections
Erratum In:
Development. 2012 Aug;139(16):3063

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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