| Fluid flows and forces in development: functions, features and biophysical principles. | |
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MedLine Citation:
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PMID: 22395739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Throughout morphogenesis, cells experience intracellular tensile and contractile forces on microscopic scales. Cells also experience extracellular forces, such as static forces mediated by the extracellular matrix and forces resulting from microscopic fluid flow. Although the biological ramifications of static forces have received much attention, little is known about the roles of fluid flows and forces during embryogenesis. Here, we focus on the microfluidic forces generated by cilia-driven fluid flow and heart-driven hemodynamics, as well as on the signaling pathways involved in flow sensing. We discuss recent studies that describe the functions and the biomechanical features of these fluid flows. These insights suggest that biological flow determines many aspects of cell behavior and identity through a specific set of physical stimuli and signaling pathways. |
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Authors:
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Jonathan B Freund; Jacky G Goetz; Kent L Hill; Julien Vermot |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 139 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-07 Completed Date: 2012-05-04 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 1229-45 Citation Subset: IM |
Affiliation:
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University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomechanics Biophysics / methods* Cilia / physiology Developmental Biology / methods* Endothelial Cells / cytology Humans Models, Biological Morphogenesis Signal Transduction Stress, Mechanical Tensile Strength Zebrafish |
| Grant Support | |
ID/Acronym/Agency:
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R01AI052348/AI/NIAID NIH HHS |
| Comments/Corrections | |
Erratum In:
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Development. 2012 Aug;139(16):3063 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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