Document Detail


Fluid-electrolyte shift and renin-aldosterone responses to exercise under hypoxia.
MedLine Citation:
PMID:  3305278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to describe fluid-electrolyte shift and endocrine response to exercise under moderate acute hypoxia, 8 healthy male subjects (24 +/- 3 years old) were evaluated at 40, 60, 80 and 100% VO2 max in normoxic (N) and hypoxic (H) conditions (14.5% O2). VO2 max decreased from 55.5 +/- 1.3 to 45.8 +/- 1.4 ml/kg X min in H condition. Plasma volume reductions with increasing relative workloads were similar in N (9.4%) and H (9.9%) conditions. The rise in plasma osmolality was in part related to blood lactate accumulation which occurred in both conditions. However, variations in plasma solute content and osmolality suggested that exercise under hypoxia results in a greater electrolyte loss from vascular space and in a greater K+ loss from working skeletal muscles. Increase in catecholamine concentrations were similar in normoxic and hypoxic conditions except for lower maximal norepinephrine concentration under hypoxia. Finally, although plasma renin activity increased with workload in both conditions, plasma aldosterone did not significantly change. This dissociation between renin and aldosterone suggest that aldosterone release during exercise might depend upon other factors. However, changes in plasma potassium concentration do not appear as an important stimulus for aldosterone secretion during exercise.
Authors:
P Bouissou; F Peronnet; G Brisson; R Helie; M Ledoux
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  19     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-10-22     Completed Date:  1987-10-22     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  331-4     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aldosterone / blood
Anoxia / physiopathology
Catecholamines / blood
Humans
Lactates / blood
Lactic Acid
Male
Oxygen Consumption
Physical Exertion*
Plasma Volume
Renin / blood
Renin-Angiotensin System*
Water-Electrolyte Balance*
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Lactates; 50-21-5/Lactic Acid; 52-39-1/Aldosterone; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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