Document Detail

Fluid and electrolyte balance during the first week of life and risk of bronchopulmonary dysplasia in the preterm neonate.
MedLine Citation:
PMID:  20668623     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Early fluid and electrolyte imbalances may be associated with an increased risk of bronchopulmonary dysplasia.
OBJECTIVE: We sought to establish an association between fluid and electrolyte balance in the first week of life and the risk of bronchopulmonary dysplasia.
METHODS: Clinical charts of 205 neonates <32 weeks gestational age and/or <1,250 g birth weight (admitted to our NICU between 1997 and 2008) were analyzed. Clinical features, fluid and electrolyte balance were analyzed for the first 7 days of life using multivariate models of generalized estimation equations. A p value <0.05 was considered significant in all of the hypothesis tests.
RESULTS: The prevalence of bronchopulmonary dysplasia was 22%. Lower gestational age and birth weight, male gender, less frequent use of antenatal steroids, respiratory distress syndrome, use of surfactant, patent ductus arteriosus, duration of invasive ventilation and NICU stay were significantly associated with bronchopulmonary dysplasia. The variation in serum values of potassium, phosphorus and creatinine during the first week of life also revealed an association with bronchopulmonary dysplasia. Higher mean plasma calcium values were associated with spontaneous closure of the patent ductus arteriosus. The use of indomethacin to induce patent ductus arteriosus closure was significantly higher in bronchopulmonary dysplasia patients.
CONCLUSIONS: Differences in renal function and tubular handling of potassium and phosphorus are present during the first week of life among preterm neonates who will develop bronchopulmonary dysplasia. The higher rate of patent ductus arteriosus and indomethacin use may influence these differences. Serum levels of calcium also appear to play a role in spontaneous ductus arteriosus closure.
Gustavo Rocha; Orquídea Ribeiro; Hercília Guimarães
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  65     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-29     Completed Date:  2011-08-11     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  663-74     Citation Subset:  IM    
Department of Pediatrics, Hospital de São João, Porto University, Portugal.
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MeSH Terms
Age Factors
Brazil / epidemiology
Bronchopulmonary Dysplasia / epidemiology,  etiology*
Infant, Low Birth Weight / metabolism
Infant, Newborn
Infant, Premature / metabolism
Kidney / physiology
Multivariate Analysis
Risk Factors
Sex Factors
Water-Electrolyte Balance / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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