| Fluid dynamics of a partially collapsible stenosis in a flow model of the coronary circulation. | |
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MedLine Citation:
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PMID: 8950652 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of passive vasomotion on the pressure drop-flow (delta P-Q) characteristics of a partially compliant stenosis was studied in an in vitro model of the coronary circulation. Twelve stenosis models of different severities (50 to 90 percent area reduction) and degrees of flexible wall (0 to 1/2 of the wall circumference) were inserted into thin-walled latex tubing and pressure and flow data were collected during simulated cardiac cycles. In general, the pressure drop increased with increasing fraction of flexible wall for a given flow rate and stenosis severity. The magnitude of this effect was directly dependent upon the underlying stenosis severity. The diastolic delta P-Q relationship of severe, compliant models exhibited features of partial collapse with an increase in pressure drop at a decreasing flow rate. It is concluded that passive vasomotion of a normal wall segment at an eccentric stenosis in response to periodic changes in intraluminal pressure causes dimensional changes in the residual lumen area which can strongly affect the hemodynamic characteristics of the stenosis during the cardiac cycle. This mechanism may have important implications for the onset of plaque fracture and the prediction of the functional significance of a coronary stenosis based on quantitative angiogram analysis. |
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Authors:
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M Siebes; C S Campbell; D Z D'Argenio |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of biomechanical engineering Volume: 118 ISSN: 0148-0731 ISO Abbreviation: J Biomech Eng Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-02-25 Completed Date: 1997-02-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7909584 Medline TA: J Biomech Eng Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 489-97 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, University of Iowa, Iowa City 52242, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Compliance Coronary Circulation / physiology* Coronary Disease / physiopathology* Hemodynamics / physiology* Humans Models, Cardiovascular* Pulsatile Flow Vascular Resistance / physiology |
| Grant Support | |
ID/Acronym/Agency:
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P41-RR01861/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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