Document Detail

Fluid compartments in hemorrhaged rats after hyperosmotic crystalloid and hyperoncotic colloid resuscitation.
MedLine Citation:
PMID:  8769817     Owner:  NLM     Status:  MEDLINE    
Postresuscitation organ failure may be associated with detrimental changes in body fluid compartments. We measured how shock and resuscitation acutely alters the interstitial, cellular, and plasma compartments in different organs. Nephrectomized, anesthetized rats were bled to 50 mmHg mean arterial pressure for 1 h, followed by 60 min of resuscitation to restore blood pressure using 0.9% normal saline (NS,n = 10), 7.5% hypertonic saline (HS,n = 8), 10% hyperoncotic albumin (HA, n = 8), or 7.5% hypertonic saline and 10% hyperoncotic albumin (HSA, n = 7). A 2-h 51Cr-EDTA distribution space estimated extracellular fluid volume (ECFV), and a 5-min 125I-labeled albumin distribution space measured plasma volume (PV). Total tissue water (TW) was measured from wet and dry weights; interstitial fluid volume (ISFV) and cell water were calculated. NS resuscitation required 7 times more fluid (50.9 +/- 7.7 vs. 8.6 +/- 0.7 for HA, 5.9 +/- 0.4 for HS, and 3.9 +/- 0.5 ml/kg for HSA), but there were no differences between solutions in whole animal PV, ECFV, or ISFV. Fluid shifts within tissues depended on resuscitation solution and type of tissue. TW was significantly reduced by hypertonic saline groups in heart, muscle, and liver (P < 0.05). ISFV was significantly reduced by HA groups in the skin. In all tissues, mean cell water in groups receiving HS was smaller; this was significant for heart, lung, muscle, and skin. In conclusion, 1) HS solutions mobilize fluid from cells while expanding both PV and ISFV, and 2) TW and cellular water increase with both isotonic crystalloids and hyperoncotic colloids in many tissues.
P F Moon; M A Hollyfield-Gilbert; T L Myers; T Uchida; G C Kramer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  270     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-12-20     Completed Date:  1996-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  F1-8     Citation Subset:  IM    
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
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MeSH Terms
Albumins / therapeutic use*
Body Fluid Compartments*
Drug Combinations
Fluid Therapy*
Isotonic Solutions / therapeutic use
Osmotic Pressure
Plasma Substitutes / therapeutic use*
Rats, Wistar
Rehydration Solutions / therapeutic use
Shock, Hemorrhagic / physiopathology*,  therapy*
Sodium Chloride / therapeutic use
Grant Support
Reg. No./Substance:
0/Albumins; 0/Drug Combinations; 0/Isotonic Solutions; 0/Plasma Substitutes; 0/Rehydration Solutions; 0/crystalloid solutions; 0/hyperoncotic albumin; 7647-14-5/Sodium Chloride

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