Document Detail

Fluid balance in the air filled alveolar space.
MedLine Citation:
PMID:  6846949     Owner:  NLM     Status:  MEDLINE    
Studies in vitro and in vivo of the alveolar epithelial membrane, which show it can normally be characterized as having a "pore radius" of 0.5 to 1.5 nm, have been presented frequently over 20 years in a number of species (2, 3, 6, 8, 12). The alveolar epithelium appears to share these permeability properties with other epithelia. The changes that can be produced in the solute permeability of the alveolar epithelium by inflation are profound and point to its fragility (table; see text) in experimental situations that are not closely controlled. It is likely that experimental results unable to demonstrate molecular sieving bear the burden of proving that this property has not been altered by the experimental procedure. The inflation changes in epithelial permeability appear restricted to situations in which only a fraction of the lung expands in response to high pressures, such as in the clinical situation of respiratory failure where much of the air space is fluid filled or atelectatic, and large distending pressures are used to ventilate a small fraction of the total alveoli. Inflation-induced permeability changes, particularly to protein, may be important in alveolar water balance or in protein-induced dysfunctions of lung surfactant in such clinical situations.
E A Egan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  127     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-06-17     Completed Date:  1983-06-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S37-9     Citation Subset:  AIM; IM    
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MeSH Terms
Biological Transport, Active
Cell Membrane Permeability
Epithelium / metabolism
Lung Volume Measurements
Pulmonary Alveoli / metabolism*
Pulmonary Gas Exchange
Water-Electrolyte Balance*

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