| Fluid administration attenuates the haemodynamic effect of frusemide in running horses. | |
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MedLine Citation:
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PMID: 9622326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of blood volume repletion after frusemide administration on the right atrial and pulmonary artery pressure responses of horses to exercise has not been reported. We examined right atrial and pulmonary artery pressure and plasma atrial natriuretic peptide concentration (ANP) responses to an incremental exercise test in 6 Standardbred mares. Horses were treated, in a 3 way cross over design, with isotonic saline, frusemide (1 mg/kg bwt, i.v.), and frusemide followed 3 h later by lactated Ringer's solution (12 ml/kg bwt, i.v.). Three and a half hours after saline or frusemide administration the horses completed a standard exercise test. Frusemide significantly affected the right atrial and pulmonary artery pressure and ANP responses to exercise. Fluid administration decreased plasma total protein concentrations at rest and during running and abolished the effects of frusemide on the haemodynamic and ANP responses to exercise. These results suggest that the haemodynamic effect of frusemide in running horses is mediated, in large part, by a reduction in plasma and blood volume. |
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Authors:
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K W Hinchcliff; K H McKeever |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Equine veterinary journal Volume: 30 ISSN: 0425-1644 ISO Abbreviation: Equine Vet. J. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-07-09 Completed Date: 1998-07-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0173320 Medline TA: Equine Vet J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 246-50 Citation Subset: IM |
Affiliation:
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Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210-1089, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Function, Right / drug effects*, physiology Atrial Natriuretic Factor / analysis Blood Proteins / analysis Blood Volume / drug effects, veterinary Body Weight Cross-Over Studies Diuretics / pharmacology*, therapeutic use Female Fluid Therapy / veterinary* Furosemide / pharmacology*, therapeutic use Heart Rate / drug effects Hematocrit / veterinary Hemodynamics / drug effects Horse Diseases / chemically induced Horses / physiology* Hypotension / chemically induced, veterinary Isotonic Solutions / administration & dosage Physical Conditioning, Animal / physiology* Pulmonary Wedge Pressure / drug effects*, physiology Sodium Chloride / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Diuretics; 0/Isotonic Solutions; 54-31-9/Furosemide; 7647-14-5/Sodium Chloride; 8026-10-6/Ringer's solution; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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