Document Detail

Fluid-Structure Interactions of the Mitral Valve and Left Heart: Comprehensive Strategies, Past, Present and Future.
MedLine Citation:
PMID:  20454531     Owner:  NLM     Status:  Publisher    
The remodeling that occurs after a posterolateral myocardial infarction can alter mitral valve function by creating conformational abnormalities in the mitral annulus and in the posteromedial papillary muscle, leading to mitral regurgitation (MR). It is generally assumed that this remodeling is caused by a volume load and is mediated by an increase in diastolic wall stress. Thus, mitral regurgitation can be both the cause and effect of an abnormal cardiac stress environment. Computational modeling of ischemic MR and its surgical correction is attractive because it enables an examination of whether a given intervention addresses the correction of regurgitation (fluid-flow) at the cost of abnormal tissue stress. This is significant because the negative effects of an increased wall stress due to the intervention will only be evident over time. However, a meaningful fluid-structure interaction model of the left heart is not trivial; it requires a careful characterization of the in-vivo cardiac geometry, tissue parameterization though inverse analysis, a robust coupled solver that handles collapsing Lagrangian interfaces, automatic grid-generation algorithms that are capable of accurately discretizing the cardiac geometry, innovations in image analysis, competent and efficient constitutive models and an understanding of the spatial organization of tissue microstructure. In this manuscript, we profile our work toward a comprehensive fluid-structure interaction model of the left heart by reviewing our early work, presenting our current work and laying out our future work in four broad categories: data collection, geometry, fluid-structure interaction and validation.
Daniel R Einstein; Facundo Del Pin; Xiangmin Jiao; Andrew P Kuprat; James P Carson; Karyn S Kunzelman; Richard P Cochran; Julius M Guccione; Mark B Ratcliffe
Publication Detail:
Journal Detail:
Title:  Communications in numerical methods in engineering     Volume:  26     ISSN:  1099-0887     ISO Abbreviation:  -     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101512257     Medline TA:  Commun Numer Methods Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  348-380     Citation Subset:  -    
Biological Monitoring & Modeling, Pacific Northwest National Laboratory, Richland, WA. { , ,
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Grant Support
R01 HL073598-04//NHLBI NIH HHS; R01 HL077921-03//NHLBI NIH HHS; R01 HL084431-02//NHLBI NIH HHS

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