| Fluent versus nonfluent primary progressive aphasia: a comparison of clinical and functional neuroimaging features. | |
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MedLine Citation:
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PMID: 15896383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To better characterize fluent and nonfluent variants of primary progressive aphasia (PPA). Although investigators have recognized both fluent and nonfluent patients with PPA, the clinical and neuroimaging features of these variants have not been fully defined. We present clinical and neuropsychological data on 47 PPA patients comparing the fluent (n=21) and nonfluent (n=26) subjects. We further compared language features with PET/SPECT data available on 39 of these patients. Compared to the nonfluent PPA patients, those with fluent PPA had greater impairment of confrontational naming and loss of single word comprehension. They also exhibited semantic paraphasic errors and loss of single word comprehension. Patients with nonfluent PPA were more likely to be female, were more often dysarthric, and exhibited phonological speech errors in the absence of semantic errors. No significant differences were seen with regard to left hemisphere abnormalities, suggesting that both variants result from mechanisms that overlap frontal, temporal, and parietal regions. Of the language measures, only semantic paraphasias were strongly localized, in this case to the left temporal lobe. Fluent and nonfluent forms of PPA are clinically distinguishable by letter fluency, single word comprehension, object naming, and types of paraphasic errors. Nevertheless, there is a large amount of overlap between dysfunctional anatomic regions associated with these syndromes. |
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Authors:
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David Glenn Clark; Anthony Charuvastra; Bruce L Miller; Jill S Shapira; Mario F Mendez |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Date: 2005-01-07 |
Journal Detail:
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Title: Brain and language Volume: 94 ISSN: 0093-934X ISO Abbreviation: Brain Lang Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-05-17 Completed Date: 2005-08-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7506220 Medline TA: Brain Lang Country: United States |
Other Details:
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Languages: eng Pagination: 54-60 Citation Subset: IM |
Affiliation:
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David Geffen School of Medicine, Department of Neurology, University of California-Los Angeles, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., 3-South Neurobehavior Unit (116AF), Los Angeles, CA 90073, USA. dgclark@mednet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aphasia, Broca / physiopathology, radionuclide imaging* Aphasia, Wernicke / physiopathology, radionuclide imaging* Dementia / physiopathology, radionuclide imaging Female Humans Male Middle Aged Positron-Emission Tomography* Tomography, Emission-Computed, Single-Photon* |
| Grant Support | |
ID/Acronym/Agency:
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AG19724-01A1/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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