| Fludarabine with cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with poor-risk chronic lymphocytic leukemia. | |
| | |
MedLine Citation:
|
PMID: 23014659 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Allogeneic stem cell transplantation (SCT) is a treatment option for patients with poor-risk chronic lymphocytic leukemia (CLL). Sequential use of chemotherapy and reduced-intensity conditioning has been proposed to improve the treatment outcomes. Fludarabine (30 mg/m(2)/day) and cytarabine (2 g/m(2)/day) for 4 days (combination of fludarabine with cytarabine; FAraC) were used for cytoreduction. After 3 days of rest, reduced intensity conditioning (RIC) was carried out consisting of 4 Gy total body irradiation, 10-20 mg/kg/day antithymocyte globulin for 3 days, and 40-60 mg/kg/day cyclophosphamide for 2 days. The median time of neutrophil engraftment was 16 days. The most frequent toxicities were grades III/IV infections in 12 of 15 cases and gastrointestinal toxicities in 8 of 15 cases. Remission (complete remission + partial remission) was achieved in 14 of 15 patients (93 %), minimal residual disease negativity according to flowcytometric analysis was observed in 10 patients. Nonrelapse mortality after 1 and 2 years was 7 and 13 %, respectively. After the median follow-up from SCT of 30 months, 80 % of patients were alive (12/15), three patients have died, and three relapses occurred. The FAraC-RIC protocol seems to be a promising approach to the treatment of poor-risk CLL with a high response rate of 93 % and favorable progression-free survival and overall survival of 70 and 85 % at 2 years after SCT, respectively. Other prospective clinical trials are needed to confirm the results of this novel therapeutic strategy. |
| | |
Authors:
|
Marta Krejci; Michael Doubek; Yvona Brychtova; Olga Stehlikova; Jana Chovancova; Boris Tichy; Hana Skuhrova Francova; Milan Navratil; Miroslav Tomiska; Ondrej Horky; Sarka Pospisilova; Jiri Mayer |
Related Documents
:
|
6295589 - Small cell undifferentiated carcinoma of the larynx. report of two patients and review ... 9364299 - Squamous cell carcinoma of the tonsil--clinical features and treatment results. 12062609 - Trimodal combination therapy for maxillary sinus carcinoma. 2993209 - Quantitative dose-response analysis of salivary function following radiotherapy using s... 23582949 - Locally advanced and metastatic prostate cancer treated with intermittent androgen mono... 218469 - Adenoid cystic carcinoma of the salivary glands. a study of ninety-three cases. 9037369 - Phase ii study of a closely spaced ifosfamide--cisplatin schedule with the addition of ... 12788409 - Isolated limb perfusion with melphalan in the treatment of malignant melanoma of the ex... 1804389 - In vitro combination of high dose busulfan with radiotherapy on medulloblastoma cells: ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-27 |
Journal Detail:
|
Title: Annals of hematology Volume: - ISSN: 1432-0584 ISO Abbreviation: Ann. Hematol. Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Masaryk University, Jihlavska 20, 625-00, Brno, Czech Republic, mkrejci@fnbrno.cz. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sandhopper Talitrus saltator (Montagu) as a Bioindicator of Contamination by Polycyclic Aromatic Hyd...
Next Document: Zoledronic acid effectiveness against breast cancer metastases - a role for estrogen in the microenv...