| Fludarabine induces differential expression of proteins in human leukemia and lymphoma cells. | |
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MedLine Citation:
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PMID: 18600519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purine analog fludarabine (FdAMP) is widely used for chemotherapy of B-lymphoid malignancies, and multiple mechanisms of action leading to apoptosis have been proposed. We examined changes at the protein level induced in the Raji cell line (Burkitt's lymphoma) by fludarabine nucleoside (FdA). Raji cells are sensitive to FdA. Raji cells treated with FdA (3 micro M, 24 hours), accumulate multiple phosphorylated forms of p53 in the nucleus that in turn degrade to phosphorylated forms of p40. Using CD antibody microarrays to determine surface expression profiles for Raji cells treated with FdA, we found up-regulation of the following CD antigens: CD20, CD54, CD80, CD86, and CD95. FdA thus induces changes in the genetic program of the cells that might be exploited to obtain synergy with therapeutic antibodies. |
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Authors:
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S Henrich; S Gez; B Crossett; S P Mulligan; R I Christopherson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleosides, nucleotides & nucleic acids Volume: 27 ISSN: 1532-2335 ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-07-07 Completed Date: 2008-10-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892832 Medline TA: Nucleosides Nucleotides Nucleic Acids Country: United States |
Other Details:
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Languages: eng Pagination: 634-40 Citation Subset: IM |
Affiliation:
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School of Molecular and Microbial Biosciences, University of Sydney, New South Wales, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies / metabolism, therapeutic use Antigens, CD / metabolism Apoptosis / drug effects Cattle Cell Line, Tumor Drug Synergism Gene Expression Regulation, Neoplastic / drug effects* Humans Leukemia / metabolism*, pathology Lymphoma / metabolism*, pathology Tumor Suppressor Protein p53 / metabolism* Vidarabine / analogs & derivatives*, metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antigens, CD; 0/Tumor Suppressor Protein p53; 21679-14-1/fludarabine; 5536-17-4/Vidarabine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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