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Fludarabine-containing chemotherapy for patients with previously untreated low-grade non-Hodgkin's lymphoma.
MedLine Citation:
PMID:  22065973     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The clinical efficacy and safety of fludarabine combination chemotherapy was investigated for the treatment of previously untreated patients with low-grade (NHL).
METHODS: Twenty-five patients who were newly diagnosed as low-grade NHL were treated with fludarabine combination chemotherapy. Fludarabine combination regimens consisted of fludarabine, mitoxantrone and dexamethasone or fludarabine, cyclophosphamide and mitoxantrone with or without rituximab and repeated every 4 weeks.
RESULTS: The median age was 60 years (range, 35-77 years), with 13 of 25 patients (52%) ≥60 years of age. Seven of 25 patients (28%) with an intermediate risk follicular lymphoma international prognostic index (FLIPI) and 9 of 25 patients (36%) with a high risk FLIPI were enrolled in this study. The delivered median number of chemotherapy was six (range, 2-9 cycles). The overall response rate with fludarabine-based treatment was 88%, including 52% complete remission and 36% partial remission. During the median follow-up of 19 months, the estimated 2-year event-free survival was 63±10% (95% CI, 43-83) and the 2-year overall survival was 78±9% (95% CI, 60-96). Fludarabine combination chemotherapy was frequently associated with grade 3 or 4 neutropenia in 84% patients. However, neutropenic infection was observed in only one (4%) patient. Four patients (16%) showed grade 3 or more non-hematologic toxicities, such as acute coronary syndrome, intracranial hemorrhage, anaphylaxis and gastric cancer.
CONCLUSION: Fludarabine-combination treatment was a highly active regimen with well toleration in untreated low-grade NHL.
Authors:
Jae-Sook Ahn; Deok-Hwan Yang; Sung-Hoon Jung; Soo-Young Bae; Huong Thi Thanh Tran; Hyung Chul Park; Ha-Na Kim; Yeo-Kyeoung Kim; Hyeoung-Joon Kim; Je-Jung Lee
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Publication Detail:
Type:  Journal Article     Date:  2011-09-30
Journal Detail:
Title:  The Korean journal of hematology     Volume:  46     ISSN:  2092-9129     ISO Abbreviation:  Korean J Hematol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-11-08     Completed Date:  2011-11-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101486388     Medline TA:  Korean J Hematol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  -    
Affiliation:
Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
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