Document Detail


Fluctuations in oscillation frequency control spike timing and coordinate neural networks.
MedLine Citation:
PMID:  24990919     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Neuroscience research spans multiple spatiotemporal scales, from subsecond dynamics of individual neurons to the slow coordination of billions of neurons during resting state and sleep. Here it is shown that a single functional principle-temporal fluctuations in oscillation peak frequency ("frequency sliding")-can be used as a common analysis approach to bridge multiple scales within neuroscience. Frequency sliding is demonstrated in simulated neural networks and in human EEG data during a visual task. Simulations of biophysically detailed neuron models show that frequency sliding modulates spike threshold and timing variability, as well as coincidence detection. Finally, human resting-state EEG data demonstrate that frequency sliding occurs endogenously and can be used to identify large-scale networks. Frequency sliding appears to be a general principle that regulates brain function on multiple spatial and temporal scales, from modulating spike timing in individual neurons to coordinating large-scale brain networks during cognition and resting state.
Authors:
Michael X Cohen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  34     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-07-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8988-98     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 the authors 0270-6474/14/348988-11$15.00/0.
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